The effect of extract Sceletium tortuosum (Zembrin®), in healthy adults-Abstract

The effect of extract Sceletium tortuosum (Zembrin®), targeting Phosphodiesterase subtype-4 (  PDE-4 ), on cognitive function: a proof-of-concept  randomized double-blind, single site, placebo-controlled cross-over study in healthy adults Abstract Simon Chiu MD PhD FRCP ( University of Western Ontario, London, Ontario, Canada) Michel Farina-Woodbury MD (University of Puerto Rico, San Juan, PR, USA); Zack Cernovsky PhD (University of Western Ontario London, Ontario, Canada); Yves Bureau PhD ( Lawson Health Research Institute,University of Western Ontario, London, Ontario, Canada) Jirui Hou PhD (Lawson Health Research Institute University of Western Ontario, London, Ontario, Canada ) Hana Raheb B. Sc. Honors Cognitive neurosciences program, University of Western Ontario Ont Kristen Terpstra B. A. Honors , Graduate program in Neurosciences McMaster Univ. Hamilton Ont. Vladimir … Continue reading

A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial of Extract Sceletium tortuosum (Zembrin®) in Healthy Adults Abstract

A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial of Extract Sceletium tortuosum (Zembrin®) in Healthy Adults Haylene Nell, Mirna Siebert, Pashini Chellan, and Nigel Gericke ABSTRACT Objectives: The objective of the study was to evaluate the safety and tolerability of two doses (8 mg and 25 mg once daily) of a 2:1 standardized extract of the South African medicinal plant Sceletium tortuosum (L.) N.E. Br., trademarked Zembrin®, in healthy adult volunteers over a three-month period. Design: This was a randomized, double-blind, parallel-group, placebo-controlled single center study. Setting: Tiervlei Trial Centre, Karl Bremer Hospital, Bellville, Cape Town, South Africa. Participants: The study took place between February 2 and July 27, 2009. Thirty-seven healthy adults were recruited from the general population. Intervention: Participants were randomized to receive either one of two doses of study medication, or … Continue reading